Human Gene NDUFC2-KCTD14 (uc021qnr.1) Description and Page Index
  Description: Homo sapiens NDUFC2-KCTD14 readthrough (NDUFC2-KCTD14), transcript variant 1, mRNA.
RefSeq Summary (NM_001203260): This locus represents naturally occurring read-through transcription between the neighboring NDUFC2 (NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2, 14.5kDa) and KCTD14 (potassium channel tetramerisation domain containing 14) genes on chromosome 11. The read-through transcripts share sequence identity with the upstream gene product and one variant has a frameshifted C-terminal region derived from the downstream gene exons. [provided by RefSeq, Feb 2011].
Transcript (Including UTRs)
   Position: hg19 chr11:77,726,761-77,791,265 Size: 64,505 Total Exon Count: 4 Strand: -
Coding Region
   Position: hg19 chr11:77,749,710-77,790,790 Size: 41,081 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsGene AllelesRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Model InformationMethods
Data last updated: 2013-06-15

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr11:77,726,761-77,791,265)mRNA (may differ from genome)Protein (134 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsH-INV
HGNCLynxMGIPubMedStanford SOURCETreefam
UniProtKB

-  Comments and Description Text from UniProtKB
  ID: E9PM14_HUMAN
DESCRIPTION: RecName: Full=NADH dehydrogenase [ubiquinone] 1 subunit C2;
FUNCTION: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
SUBCELLULAR LOCATION: Mitochondrion inner membrane (By similarity).
SIMILARITY: Belongs to the complex I NDUFC2 subunit family.
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 3.05 RPKM in Adrenal Gland
Total median expression: 18.07 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -177.24475-0.373 Picture PostScript Text
3' UTR -495.521556-0.318 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR009423 - NADH-UbQ_OxRdtase_b14.5b_su

Pfam Domains:
PF06374 - NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2)

ModBase Predicted Comparative 3D Structure on E9PM14
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0008137 NADH dehydrogenase (ubiquinone) activity

Biological Process:
GO:0006120 mitochondrial electron transport, NADH to ubiquinone
GO:0055114 oxidation-reduction process

Cellular Component:
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0070469 respiratory chain


-  Descriptions from all associated GenBank mRNAs
  BC001062 - Homo sapiens potassium channel tetramerisation domain containing 14, mRNA (cDNA clone MGC:2376 IMAGE:2819500), complete cds.
BC001929 - Homo sapiens potassium channel tetramerisation domain containing 14, mRNA (cDNA clone MGC:3993 IMAGE:2819500), complete cds.
JD511870 - Sequence 492894 from Patent EP1572962.
JD304428 - Sequence 285452 from Patent EP1572962.
JD538534 - Sequence 519558 from Patent EP1572962.
JD226737 - Sequence 207761 from Patent EP1572962.
JD400930 - Sequence 381954 from Patent EP1572962.
JD547289 - Sequence 528313 from Patent EP1572962.
JD073141 - Sequence 54165 from Patent EP1572962.
JD258252 - Sequence 239276 from Patent EP1572962.
JD079325 - Sequence 60349 from Patent EP1572962.
JD510528 - Sequence 491552 from Patent EP1572962.
JD185231 - Sequence 166255 from Patent EP1572962.
JD360456 - Sequence 341480 from Patent EP1572962.
JD093677 - Sequence 74701 from Patent EP1572962.
JD563018 - Sequence 544042 from Patent EP1572962.
AK313892 - Homo sapiens cDNA, FLJ94527.
KJ903127 - Synthetic construct Homo sapiens clone ccsbBroadEn_12521 KCTD14 gene, encodes complete protein.
DQ892742 - Synthetic construct clone IMAGE:100005372; FLH189281.01X; RZPDo839D0674D potassium channel tetramerisation domain containing 14 (KCTD14) gene, encodes complete protein.
DQ895988 - Synthetic construct Homo sapiens clone IMAGE:100010448; FLH189277.01L; RZPDo839D0664D potassium channel tetramerisation domain containing 14 (KCTD14) gene, encodes complete protein.
AB464660 - Synthetic construct DNA, clone: pF1KB8766, Homo sapiens KCTD14 gene for potassium channel tetramerisation domain containing 14, without stop codon, in Flexi system.
AF369951 - Homo sapiens lung cancer oncogene 1 mRNA, complete cds.
LF384289 - JP 2014500723-A/191792: Polycomb-Associated Non-Coding RNAs.
AK098173 - Homo sapiens cDNA FLJ40854 fis, clone TRACH2016286, moderately similar to NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT B14.5B (EC 1.6.5.3).
BC007323 - Homo sapiens NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2, 14.5kDa, mRNA (cDNA clone MGC:1432 IMAGE:2990086), complete cds.
AK023013 - Homo sapiens cDNA FLJ12951 fis, clone NT2RP2005457, highly similar to Homo sapiens NADH-ubiquinone oxidoreductase subunit B14.5B homolog mRNA.
AF087899 - Homo sapiens NADH dehydrogenase mRNA, complete cds.
AL050278 - Homo sapiens mRNA; cDNA DKFZp566G163 (from clone DKFZp566G163).
AF070652 - Homo sapiens NADH-ubiquinone oxidoreductase subunit B14.5B homolog mRNA, complete cds.
AK022785 - Homo sapiens cDNA FLJ12723 fis, clone NT2RP1001361, highly similar to Homo sapiens NADH-ubiquinone oxidoreductase subunit B14.5B homolog mRNA.
AF087659 - Homo sapiens NADH-ubiquinone oxidoreductase B14.5B subunit mRNA, complete cds, nuclear gene encoding mitochondrial protein.
AF369952 - Homo sapiens HLC-2 mRNA, complete cds.
CR533448 - Homo sapiens full open reading frame cDNA clone RZPDo834E1216D for gene NDUFC2, NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2, 14.5kDa; complete cds, incl. stopcodon.
KJ897230 - Synthetic construct Homo sapiens clone ccsbBroadEn_06624 NDUFC2 gene, encodes complete protein.
AB528753 - Synthetic construct DNA, clone: pF1KE0151, Homo sapiens NDUFC2 gene for NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2, 14.5kDa, without stop codon, in Flexi system.
AM392713 - Synthetic construct Homo sapiens clone IMAGE:100001805 for hypothetical protein (NDUFC2 gene).
LF369003 - JP 2014500723-A/176506: Polycomb-Associated Non-Coding RNAs.
LF369000 - JP 2014500723-A/176503: Polycomb-Associated Non-Coding RNAs.
JD471394 - Sequence 452418 from Patent EP1572962.
MA619866 - JP 2018138019-A/191792: Polycomb-Associated Non-Coding RNAs.
MA604580 - JP 2018138019-A/176506: Polycomb-Associated Non-Coding RNAs.
MA604577 - JP 2018138019-A/176503: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: E9PM14, E9PM14_HUMAN, NDUFC2, NM_001203260, NP_001190189
UCSC ID: uc021qnr.1
RefSeq Accession: NM_001203260
Protein: E9PM14

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001203260.1
exon count: 4CDS single in 3' UTR: no RNA size: 2436
ORF size: 405CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 787.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.