Human Gene NDUFC2 (uc021qnv.1) Description and Page Index
  Description: Homo sapiens NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2, 14.5kDa (NDUFC2), nuclear gene encoding mitochondrial protein, transcript variant 2, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr11:77,779,393-77,791,265 Size: 11,873 Total Exon Count: 3 Strand: -
Coding Region
   Position: hg19 chr11:77,780,919-77,790,790 Size: 9,872 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDGene Alleles
Microarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA DescriptionsPathways
Other NamesModel InformationMethods
Data last updated: 2013-06-15

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr11:77,779,393-77,791,265)mRNA (may differ from genome)Protein (88 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
H-INVHGNCLynxMGIOMIMPubMed
Stanford SOURCETreefamUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: E9PNU8_HUMAN
DESCRIPTION: SubName: Full=NADH dehydrogenase [ubiquinone] 1 subunit C2;
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): NDUFC2
CDC HuGE Published Literature: NDUFC2

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
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+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -177.24475-0.373 Picture PostScript Text
3' UTR -630.901526-0.413 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR009423 - NADH-UbQ_OxRdtase_b14.5b_su

Pfam Domains:
PF06374 - NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2)

ModBase Predicted Comparative 3D Structure on E9PNU8
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Descriptions from all associated GenBank mRNAs
  AF369951 - Homo sapiens lung cancer oncogene 1 mRNA, complete cds.
LF384289 - JP 2014500723-A/191792: Polycomb-Associated Non-Coding RNAs.
AK098173 - Homo sapiens cDNA FLJ40854 fis, clone TRACH2016286, moderately similar to NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT B14.5B (EC 1.6.5.3).
BC007323 - Homo sapiens NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2, 14.5kDa, mRNA (cDNA clone MGC:1432 IMAGE:2990086), complete cds.
AK023013 - Homo sapiens cDNA FLJ12951 fis, clone NT2RP2005457, highly similar to Homo sapiens NADH-ubiquinone oxidoreductase subunit B14.5B homolog mRNA.
JD505845 - Sequence 486869 from Patent EP1572962.
JD296876 - Sequence 277900 from Patent EP1572962.
JD119897 - Sequence 100921 from Patent EP1572962.
JD100215 - Sequence 81239 from Patent EP1572962.
JD541879 - Sequence 522903 from Patent EP1572962.
JD492887 - Sequence 473911 from Patent EP1572962.
JD198404 - Sequence 179428 from Patent EP1572962.
JD272038 - Sequence 253062 from Patent EP1572962.
JD559314 - Sequence 540338 from Patent EP1572962.
JD198405 - Sequence 179429 from Patent EP1572962.
JD272039 - Sequence 253063 from Patent EP1572962.
JD559315 - Sequence 540339 from Patent EP1572962.
JD375517 - Sequence 356541 from Patent EP1572962.
JD366617 - Sequence 347641 from Patent EP1572962.
JD426544 - Sequence 407568 from Patent EP1572962.
JD135300 - Sequence 116324 from Patent EP1572962.
JD194520 - Sequence 175544 from Patent EP1572962.
JD071199 - Sequence 52223 from Patent EP1572962.
JD106017 - Sequence 87041 from Patent EP1572962.
JD187344 - Sequence 168368 from Patent EP1572962.
JD535519 - Sequence 516543 from Patent EP1572962.
JD156239 - Sequence 137263 from Patent EP1572962.
JD513116 - Sequence 494140 from Patent EP1572962.
JD281334 - Sequence 262358 from Patent EP1572962.
JD232322 - Sequence 213346 from Patent EP1572962.
JD561704 - Sequence 542728 from Patent EP1572962.
JD235064 - Sequence 216088 from Patent EP1572962.
JD279732 - Sequence 260756 from Patent EP1572962.
JD117519 - Sequence 98543 from Patent EP1572962.
JD047613 - Sequence 28637 from Patent EP1572962.
JD363141 - Sequence 344165 from Patent EP1572962.
JD134566 - Sequence 115590 from Patent EP1572962.
JD058465 - Sequence 39489 from Patent EP1572962.
JD144564 - Sequence 125588 from Patent EP1572962.
JD417492 - Sequence 398516 from Patent EP1572962.
JD548051 - Sequence 529075 from Patent EP1572962.
JD548049 - Sequence 529073 from Patent EP1572962.
JD482705 - Sequence 463729 from Patent EP1572962.
JD294355 - Sequence 275379 from Patent EP1572962.
JD482704 - Sequence 463728 from Patent EP1572962.
JD355943 - Sequence 336967 from Patent EP1572962.
JD112079 - Sequence 93103 from Patent EP1572962.
JD380424 - Sequence 361448 from Patent EP1572962.
JD522235 - Sequence 503259 from Patent EP1572962.
JD556280 - Sequence 537304 from Patent EP1572962.
JD556279 - Sequence 537303 from Patent EP1572962.
JD532306 - Sequence 513330 from Patent EP1572962.
JD377518 - Sequence 358542 from Patent EP1572962.
JD483181 - Sequence 464205 from Patent EP1572962.
JD066634 - Sequence 47658 from Patent EP1572962.
JD341778 - Sequence 322802 from Patent EP1572962.
JD167284 - Sequence 148308 from Patent EP1572962.
JD327612 - Sequence 308636 from Patent EP1572962.
JD313812 - Sequence 294836 from Patent EP1572962.
JD360090 - Sequence 341114 from Patent EP1572962.
JD286442 - Sequence 267466 from Patent EP1572962.
JD295015 - Sequence 276039 from Patent EP1572962.
JD488953 - Sequence 469977 from Patent EP1572962.
JD182242 - Sequence 163266 from Patent EP1572962.
JD161774 - Sequence 142798 from Patent EP1572962.
JD527842 - Sequence 508866 from Patent EP1572962.
JD532147 - Sequence 513171 from Patent EP1572962.
JD059996 - Sequence 41020 from Patent EP1572962.
AF087899 - Homo sapiens NADH dehydrogenase mRNA, complete cds.
JD524054 - Sequence 505078 from Patent EP1572962.
JD557831 - Sequence 538855 from Patent EP1572962.
AL050278 - Homo sapiens mRNA; cDNA DKFZp566G163 (from clone DKFZp566G163).
AF070652 - Homo sapiens NADH-ubiquinone oxidoreductase subunit B14.5B homolog mRNA, complete cds.
AK022785 - Homo sapiens cDNA FLJ12723 fis, clone NT2RP1001361, highly similar to Homo sapiens NADH-ubiquinone oxidoreductase subunit B14.5B homolog mRNA.
AF087659 - Homo sapiens NADH-ubiquinone oxidoreductase B14.5B subunit mRNA, complete cds, nuclear gene encoding mitochondrial protein.
AF369952 - Homo sapiens HLC-2 mRNA, complete cds.
JD348460 - Sequence 329484 from Patent EP1572962.
CR533448 - Homo sapiens full open reading frame cDNA clone RZPDo834E1216D for gene NDUFC2, NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2, 14.5kDa; complete cds, incl. stopcodon.
KJ897230 - Synthetic construct Homo sapiens clone ccsbBroadEn_06624 NDUFC2 gene, encodes complete protein.
AB528753 - Synthetic construct DNA, clone: pF1KE0151, Homo sapiens NDUFC2 gene for NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2, 14.5kDa, without stop codon, in Flexi system.
AM392713 - Synthetic construct Homo sapiens clone IMAGE:100001805 for hypothetical protein (NDUFC2 gene).
LF369000 - JP 2014500723-A/176503: Polycomb-Associated Non-Coding RNAs.
JD471394 - Sequence 452418 from Patent EP1572962.
MA619866 - JP 2018138019-A/191792: Polycomb-Associated Non-Coding RNAs.
MA604577 - JP 2018138019-A/176503: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa00190 - Oxidative phosphorylation
hsa01100 - Metabolic pathways
hsa05010 - Alzheimer's disease
hsa05012 - Parkinson's disease
hsa05016 - Huntington's disease

-  Other Names for This Gene
  Alternate Gene Symbols: E9PNU8, E9PNU8_HUMAN, NM_001204054, NP_001190983
UCSC ID: uc021qnv.1
RefSeq Accession: NM_001204054
Protein: E9PNU8 CCDS: CCDS55781.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001204054.1
exon count: 3CDS single in 3' UTR: no RNA size: 2284
ORF size: 267CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 470.00frame shift in genome: no % Coverage: 99.30
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.