Human Gene TMEM136 (uc021qrl.1) Description and Page Index
  Description: Homo sapiens transmembrane protein 136 (TMEM136), transcript variant 5, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr11:120,195,838-120,204,388 Size: 8,551 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg19 chr11:120,200,790-120,201,224 Size: 435 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated: 2013-06-15

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr11:120,195,838-120,204,388)mRNA (may differ from genome)Protein (144 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
PubMedStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Transmembrane protein 136;
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential).
SIMILARITY: Belongs to the TMEM136 family.
SIMILARITY: Contains 1 TLC (TRAM/LAG1/CLN8) domain.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 8.40 RPKM in Adrenal Gland
Total median expression: 224.19 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -203.40519-0.392 Picture PostScript Text
3' UTR -924.573164-0.292 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR006634 - TLC-dom

Pfam Domains:
PF03798 - TLC domain

ModBase Predicted Comparative 3D Structure on Q6ZRR5
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane

-  Descriptions from all associated GenBank mRNAs
  AK128040 - Homo sapiens cDNA FLJ46159 fis, clone TESTI4002072.
AK304086 - Homo sapiens cDNA FLJ61537 complete cds.
AK096207 - Homo sapiens cDNA FLJ38888 fis, clone MESAN2018699.
AK289680 - Homo sapiens cDNA FLJ78133 complete cds.
AK294713 - Homo sapiens cDNA FLJ52158 complete cds.
BC015232 - Homo sapiens transmembrane protein 136, mRNA (cDNA clone MGC:17839 IMAGE:3900115), complete cds.
KJ895841 - Synthetic construct Homo sapiens clone ccsbBroadEn_05235 TMEM136 gene, encodes complete protein.
JD026246 - Sequence 7270 from Patent EP1572962.
JD033817 - Sequence 14841 from Patent EP1572962.
AK096813 - Homo sapiens cDNA FLJ39494 fis, clone PROST2016444.
JD352345 - Sequence 333369 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: B4DGQ4, B4E230, NM_001198673, NP_001185602, Q6ZRR5, Q8IZ79, TM136_HUMAN
UCSC ID: uc021qrl.1
RefSeq Accession: NM_001198673
Protein: Q6ZRR5 (aka TM136_HUMAN)

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_001198673.1
exon count: 3CDS single in 3' UTR: no RNA size: 4118
ORF size: 435CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 790.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: yes # AT/AC introns 0
selenocysteine: no end bleed into intron: 3630# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.