Human Gene SLC25A11 (uc021tod.1) Description and Page Index
  Description: Homo sapiens solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11 (SLC25A11), nuclear gene encoding mitochondrial protein, transcript variant 2, mRNA.
RefSeq Summary (NM_001165417): The oxoglutarate/malate carrier transports 2-oxoglutarate across the inner membranes of mitochondria in an electroneutral exchange for malate or other dicarboxylic acids (summary by Iacobazzi et al., 1992 [PubMed 1457818]).[supplied by OMIM, Jan 2011].
Transcript (Including UTRs)
   Position: hg19 chr17:4,840,426-4,843,462 Size: 3,037 Total Exon Count: 8 Strand: -
Coding Region
   Position: hg19 chr17:4,841,036-4,843,205 Size: 2,170 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-15

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr17:4,840,426-4,843,462)mRNA (may differ from genome)Protein (303 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
H-INVHGNCLynxMGIOMIMPubMed
Stanford SOURCETreefamUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: I3L1P8_HUMAN
DESCRIPTION: SubName: Full=Mitochondrial 2-oxoglutarate/malate carrier protein; Flags: Fragment;
SIMILARITY: Belongs to the mitochondrial carrier family.
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): SLC25A11
CDC HuGE Published Literature: SLC25A11

-  MalaCards Disease Associations
  MalaCards Gene Search: SLC25A11
Diseases sorted by gene-association score: breast leiomyosarcoma (4), oculogyric crisis (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 91.21 RPKM in Heart - Left Ventricle
Total median expression: 1964.71 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -127.80257-0.497 Picture PostScript Text
3' UTR -233.53610-0.383 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR018108 - Mitochondrial_sb/sol_carrier
IPR023395 - Mt_carrier_dom

Pfam Domains:
PF00153 - Mitochondrial carrier protein

SCOP Domains:
103506 - Mitochondrial carrier

ModBase Predicted Comparative 3D Structure on I3L1P8
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  BC006508 - Homo sapiens solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11, mRNA (cDNA clone MGC:2449 IMAGE:2960933), complete cds.
BC006519 - Homo sapiens solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11, mRNA (cDNA clone MGC:4128 IMAGE:2960933), complete cds.
BC017170 - Homo sapiens solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11, mRNA (cDNA clone MGC:8575 IMAGE:2960933), complete cds.
BC016294 - Homo sapiens solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11, mRNA (cDNA clone MGC:9623 IMAGE:3911858), complete cds.
AF070548 - Homo sapiens clone 24408 2-oxoglutarate carrier protein mRNA, complete cds.
BC016473 - Homo sapiens solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11, mRNA (cDNA clone IMAGE:4186740), with apparent retained intron.
AK290376 - Homo sapiens cDNA FLJ76014 complete cds, highly similar to Homo sapiens solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11 (SLC25A11), mRNA.
JD282805 - Sequence 263829 from Patent EP1572962.
JD090534 - Sequence 71558 from Patent EP1572962.
JD065297 - Sequence 46321 from Patent EP1572962.
JD186346 - Sequence 167370 from Patent EP1572962.
JD361887 - Sequence 342911 from Patent EP1572962.
JD434343 - Sequence 415367 from Patent EP1572962.
JD097281 - Sequence 78305 from Patent EP1572962.
JD236348 - Sequence 217372 from Patent EP1572962.
JD279800 - Sequence 260824 from Patent EP1572962.
JD054867 - Sequence 35891 from Patent EP1572962.
JD200307 - Sequence 181331 from Patent EP1572962.
JD425975 - Sequence 406999 from Patent EP1572962.
JD537964 - Sequence 518988 from Patent EP1572962.
JD461668 - Sequence 442692 from Patent EP1572962.
AK313010 - Homo sapiens cDNA, FLJ93475.
KJ892526 - Synthetic construct Homo sapiens clone ccsbBroadEn_01920 SLC25A11 gene, encodes complete protein.
CU677597 - Synthetic construct Homo sapiens gateway clone IMAGE:100018858 5' read SLC25A11 mRNA.
DQ891152 - Synthetic construct clone IMAGE:100003782; FLH169790.01X; RZPDo839G0296D solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11 (SLC25A11) gene, encodes complete protein.
DQ894331 - Synthetic construct Homo sapiens clone IMAGE:100008791; FLH169786.01L; RZPDo839G0295D solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11 (SLC25A11) gene, encodes complete protein.
CR456834 - Homo sapiens full open reading frame cDNA clone RZPDo834F0618D for gene SLC25A11, solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11; complete cds, incl. stopcodon.
JD223507 - Sequence 204531 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_malatexPathway - Shuttle for transfer of acetyl groups from mitochondria to the cytosol
h_malatePathway - Malate-aspartate shuttle

-  Other Names for This Gene
  Alternate Gene Symbols: I3L1P8, I3L1P8_HUMAN, NM_001165417, NP_001158889
UCSC ID: uc021tod.1
RefSeq Accession: NM_001165417
Protein: I3L1P8 CCDS: CCDS11059.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001165417.1
exon count: 8CDS single in 3' UTR: no RNA size: 1789
ORF size: 912CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2024.00frame shift in genome: no % Coverage: 99.44
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.