Human Gene SLC25A11 (uc021tod.1) Description and Page Index
Description: Homo sapiens solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11 (SLC25A11), nuclear gene encoding mitochondrial protein, transcript variant 2, mRNA. RefSeq Summary (NM_001165417): The oxoglutarate/malate carrier transports 2-oxoglutarate across the inner membranes of mitochondria in an electroneutral exchange for malate or other dicarboxylic acids (summary by Iacobazzi et al., 1992 [PubMed 1457818]).[supplied by OMIM, Jan 2011]. Transcript (Including UTRs) Position: hg19 chr17:4,840,426-4,843,462 Size: 3,037 Total Exon Count: 8 Strand: - Coding Region Position: hg19 chr17:4,841,036-4,843,205 Size: 2,170 Coding Exon Count: 8
ID:I3L1P8_HUMAN DESCRIPTION: SubName: Full=Mitochondrial 2-oxoglutarate/malate carrier protein; Flags: Fragment; SIMILARITY: Belongs to the mitochondrial carrier family. CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): SLC25A11 CDC HuGE Published Literature: SLC25A11
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on I3L1P8
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.