Human Gene MEAF6 (uc031plz.1) Description and Page Index
  Description: Homo sapiens MYST/Esa1-associated factor 6 (MEAF6), transcript variant 3, mRNA.
RefSeq Summary (NM_001270876): This gene encodes a nuclear protein involved in transcriptional activation. The encoded protein may form a component of several different histone acetyltransferase complexes. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012].
Transcript (Including UTRs)
   Position: hg19 chr1:37,955,561-37,980,420 Size: 24,860 Total Exon Count: 6 Strand: -
Coding Region
   Position: hg19 chr1:37,959,370-37,980,347 Size: 20,978 Coding Exon Count: 6 

Page IndexSequence and LinksMalaCardsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA DescriptionsOther Names
Model InformationMethods
Data last updated: 2013-06-15

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr1:37,955,561-37,980,420)mRNA (may differ from genome)Protein (192 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
Stanford SOURCEUniProtKBWikipedia

-  MalaCards Disease Associations
  MalaCards Gene Search: MEAF6
Diseases sorted by gene-association score: endometrial stromal sarcoma (4)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 36.71 RPKM in Pituitary
Total median expression: 782.16 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -39.5073-0.541 Picture PostScript Text
3' UTR -1396.133809-0.367 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR015418 - Hist_AcTrfase_NuA4_cplx

Pfam Domains:
PF09340 - Histone acetyltransferase subunit NuA4

ModBase Predicted Comparative 3D Structure on B1AK64
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologGenome BrowserNo orthologNo ortholog
Gene Details  Gene Details  
Gene Sorter  Gene Sorter  
   Protein Sequence  

-  Descriptions from all associated GenBank mRNAs
  AF172817 - Homo sapiens MSTP088 (MST088) mRNA, complete cds.
JD365206 - Sequence 346230 from Patent EP1572962.
JD125648 - Sequence 106672 from Patent EP1572962.
JD192063 - Sequence 173087 from Patent EP1572962.
JD395440 - Sequence 376464 from Patent EP1572962.
JD481335 - Sequence 462359 from Patent EP1572962.
BX640719 - Homo sapiens mRNA; cDNA DKFZp686D18202 (from clone DKFZp686D18202).
LF383907 - JP 2014500723-A/191410: Polycomb-Associated Non-Coding RNAs.
BX538212 - Homo sapiens mRNA; cDNA DKFZp686L05272 (from clone DKFZp686L05272); complete cds.
AK225598 - Homo sapiens mRNA for hypothetical protein LOC64769 variant, clone: PNC04154.
BC016328 - Homo sapiens chromosome 1 open reading frame 149, mRNA (cDNA clone MGC:23733 IMAGE:4102633), complete cds.
AY007166 - Homo sapiens clone CDABP0189 mRNA sequence.
BC043239 - Homo sapiens chromosome 1 open reading frame 149, mRNA (cDNA clone IMAGE:5295869), with apparent retained intron.
BC056406 - Homo sapiens chromosome 1 open reading frame 149, mRNA (cDNA clone MGC:64866 IMAGE:6471256), complete cds.
AK021792 - Homo sapiens cDNA FLJ11730 fis, clone HEMBA1005403.
AK309663 - Homo sapiens cDNA, FLJ99704.
AK308118 - Homo sapiens cDNA, FLJ98066.
AY211926 - Homo sapiens sarcoma antigen NY-SAR-91 mRNA, partial cds.
JD228444 - Sequence 209468 from Patent EP1572962.
AK225434 - Homo sapiens mRNA for hypothetical protein LOC64769 variant, clone: HSI01267.
AB463504 - Synthetic construct DNA, clone: pF1KB6886, Homo sapiens C1orf149 gene for chromosome 1 open reading frame 149, without stop codon, in Flexi system.
HQ448659 - Synthetic construct Homo sapiens clone IMAGE:100072100; CCSB007537_01 chromosome 1 open reading frame 149 (C1orf149) gene, encodes complete protein.
KJ903092 - Synthetic construct Homo sapiens clone ccsbBroadEn_12486 MEAF6 gene, encodes complete protein.
EU831681 - Synthetic construct Homo sapiens clone HAIB:100066710; DKFZo003B0320 chromosome 1 open reading frame 149 protein (C1orf149) gene, encodes complete protein.
EU832519 - Synthetic construct Homo sapiens clone HAIB:100067548; DKFZo008H0329 chromosome 1 open reading frame 149 protein (C1orf149) gene, encodes complete protein.
EU832600 - Synthetic construct Homo sapiens clone HAIB:100067629; DKFZo004H0330 chromosome 1 open reading frame 149 protein (C1orf149) gene, encodes complete protein.
DQ099384 - Homo sapiens sarcoma antigen NY-SAR-91 mRNA, complete cds, alternatively spliced.
CU677607 - Synthetic construct Homo sapiens gateway clone IMAGE:100017558 5' read C1orf149 mRNA.
JD458356 - Sequence 439380 from Patent EP1572962.
JD406035 - Sequence 387059 from Patent EP1572962.
MA619484 - JP 2018138019-A/191410: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: B1AK64, B1AK64_HUMAN, C1orf149, NM_001270876, NP_001257805, RP3-423B22.2-008, uc001cbe.1
UCSC ID: uc031plz.1
RefSeq Accession: NM_001270876
Protein: B1AK64 CCDS: CCDS59195.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_001270876.1
exon count: 6CDS single in 3' UTR: no RNA size: 4461
ORF size: 579CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1358.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.