Human Gene PGAP2 (uc031pyo.1) Description and Page Index
Description: Homo sapiens post-GPI attachment to proteins 2 (PGAP2), transcript variant 11, mRNA. RefSeq Summary (NM_001256239): The protein encoded by this gene plays a role in the maturation of glycosylphosphatidylinositol (GPI) anchors on GPI-anchored proteins. Mutations in this gene are associated with an autosomal recessive syndrome characterized by hyperphosphatasia and intellectual disability. [provided by RefSeq, Jul 2017]. Transcript (Including UTRs) Position: hg19 chr11:3,829,766-3,847,601 Size: 17,836 Total Exon Count: 6 Strand: + Coding Region Position: hg19 chr11:3,832,490-3,846,688 Size: 14,199 Coding Exon Count: 5
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9UHJ9-3
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.