Human Gene CORO1C (uc031qjk.1) Description and Page Index
Description: Homo sapiens coronin, actin binding protein, 1C (CORO1C), transcript variant 3, mRNA. RefSeq Summary (NM_001276471): This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2013]. Transcript (Including UTRs) Position: hg19 chr12:109,038,885-109,124,619 Size: 85,735 Total Exon Count: 11 Strand: - Coding Region Position: hg19 chr12:109,041,179-109,095,094 Size: 53,916 Coding Exon Count: 10
Diabetes Mellitus, Type 2 Laura J Scott et al. Science (New York, N.Y.) 2007, A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants., Science (New York, N.Y.).
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9ULV4
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0001755 neural crest cell migration GO:0001932 regulation of protein phosphorylation GO:0001933 negative regulation of protein phosphorylation GO:0006909 phagocytosis GO:0007165 signal transduction GO:0010632 regulation of epithelial cell migration GO:0010633 negative regulation of epithelial cell migration GO:0010762 regulation of fibroblast migration GO:0030036 actin cytoskeleton organization GO:0044387 negative regulation of protein kinase activity by regulation of protein phosphorylation GO:0045184 establishment of protein localization GO:0051893 regulation of focal adhesion assembly GO:0051895 negative regulation of focal adhesion assembly GO:0090630 activation of GTPase activity GO:1900024 regulation of substrate adhesion-dependent cell spreading GO:1900025 negative regulation of substrate adhesion-dependent cell spreading GO:1900027 regulation of ruffle assembly GO:2000394 positive regulation of lamellipodium morphogenesis