Mouse Gene Tmprss2 (ENSMUST00000000395.8) from GENCODE VM33
  Description: Mus musculus transmembrane protease, serine 2 (Tmprss2), mRNA. (from RefSeq NM_015775)
Gencode Transcript: ENSMUST00000000395.8
Gencode Gene: ENSMUSG00000000385.9
Transcript (Including UTRs)
   Position: mm39 chr16:97,365,882-97,412,395 Size: 46,514 Total Exon Count: 14 Strand: -
Coding Region
   Position: mm39 chr16:97,367,340-97,400,469 Size: 33,130 Coding Exon Count: 13 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther NamesMethods
Data last updated at UCSC: 2023-08-16 11:06:27

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr16:97,365,882-97,412,395)mRNA (may differ from genome)Protein (490 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaAlphaFoldBioGPS
EnsemblEntrez GeneExonPrimerGeneCardsMGIPubMed

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Transmembrane protease serine 2; EC=3.4.21.-; AltName: Full=Epitheliasin; AltName: Full=Plasmic transmembrane protein X; Contains: RecName: Full=Transmembrane protease serine 2 non-catalytic chain; Contains: RecName: Full=Transmembrane protease serine 2 catalytic chain;
SUBCELLULAR LOCATION: Cell membrane; Single-pass type II membrane protein (By similarity).
SUBCELLULAR LOCATION: Transmembrane protease serine 2 catalytic chain: Secreted (By similarity). Note=Activated by cleavage and secreted (By similarity).
TISSUE SPECIFICITY: Expressed mainly in prostate and kidney.
SIMILARITY: Belongs to the peptidase S1 family.
SIMILARITY: Contains 1 LDL-receptor class A domain.
SIMILARITY: Contains 1 peptidase S1 domain.
SIMILARITY: Contains 1 SRCR domain.

-  Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -91.20230-0.397 Picture PostScript Text
3' UTR -479.701458-0.329 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR023415 - LDLR_class-A_CS
IPR002172 - LDrepeatLR_classA_rpt
IPR009003 - Pept_cys/ser_Trypsin-like
IPR018114 - Peptidase_S1/S6_AS
IPR001254 - Peptidase_S1_S6
IPR001314 - Peptidase_S1A
IPR001190 - Srcr_rcpt
IPR017448 - Srcr_rcpt-rel

Pfam Domains:
PF00057 - Low-density lipoprotein receptor domain class A
PF00530 - Scavenger receptor cysteine-rich domain
PF00089 - Trypsin

ModBase Predicted Comparative 3D Structure on Q9JIQ8
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein SequenceProtein Sequence   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004252 serine-type endopeptidase activity
GO:0005044 scavenger receptor activity
GO:0008233 peptidase activity
GO:0008236 serine-type peptidase activity
GO:0016787 hydrolase activity

Biological Process:
GO:0006508 proteolysis
GO:0006898 receptor-mediated endocytosis
GO:0016540 protein autoprocessing
GO:0046598 positive regulation of viral entry into host cell

Cellular Component:
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane

-  Descriptions from all associated GenBank mRNAs
  BC038393 - Mus musculus transmembrane protease, serine 2, mRNA (cDNA clone MGC:6821 IMAGE:2648878), complete cds.
BC054348 - Mus musculus transmembrane protease, serine 2, mRNA (cDNA clone MGC:62602 IMAGE:2648889), complete cds.
AK141350 - Mus musculus 7 days embryo whole body cDNA, RIKEN full-length enriched library, clone:C430036M12 product:transmembrane protease, serine 2, full insert sequence.
AK146047 - Mus musculus 14 days pregnant adult female placenta cDNA, RIKEN full-length enriched library, clone:I530026G04 product:transmembrane protease, serine 2, full insert sequence.
AF113596 - Mus musculus mosaic serine protease epitheliasin mRNA, complete cds.
AF243500 - Mus musculus plasmic transmembrane protein X mRNA, complete cds.
AK161173 - Mus musculus 0 day neonate head cDNA, RIKEN full-length enriched library, clone:4831434G08 product:transmembrane protease, serine 2, full insert sequence.
AF199362 - Mus musculus serine protease TMPRSS2 (Tmprss2) mRNA, complete cds.

-  Other Names for This Gene
  Alternate Gene Symbols: ENSMUST00000000395.1, ENSMUST00000000395.2, ENSMUST00000000395.3, ENSMUST00000000395.4, ENSMUST00000000395.5, ENSMUST00000000395.6, ENSMUST00000000395.7, NM_015775, Q7TN04, Q9JIQ8, Q9JKC4, Q9QY82, TMPS2_MOUSE, uc008adl.1, uc008adl.2
UCSC ID: ENSMUST00000000395.8
RefSeq Accession: NM_015775
Protein: Q9JIQ8 (aka TMPS2_MOUSE or TMS2_MOUSE)

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.