We have a suspicion that you are an automated web bot software, not a real user. To keep our site fast for other users, we have slowed down this page. The slowdown will gradually disappear. If you think this is a mistake, please contact us at genome-www@soe.ucsc.edu. Also note that all data for hgGeneGraph can be obtained through our public MySQL server and all our software source code is available and can be installed locally onto your own computer. If you are unsure how to use these resources, do not hesitate to contact us.
UCSC Genome Browser Gene Interaction Graph
Gene interactions and pathways from curated databases and text-mining

◀ Back to MTOR

MTOR — NF2

Text-mined interactions from Literome

Dasgupta et al., Cancer Res 2005 (Astrocytoma...) : Recent studies from our laboratory have shown that neurofibromin also regulates the mammalian target of rapamycin activity in a Ras dependent fashion, and that the rapamycin mediated mammalian target of rapamycin inhibition ameliorates the Nf1-/- astrocyte growth advantage
Hegedus et al., Cancer Res 2008 (Disease Models, Animal...) : Because neurofibromin negatively regulates mammalian target of rapamycin (mTOR) signaling , we showed that pharmacologic mTOR inhibition in vivo led to decreased tumor cell proliferation in a dose dependent fashion associated with a decrease in tumor volume ... Because neurofibromin negatively regulates mammalian target of rapamycin (mTOR) signaling, we showed that pharmacologic mTOR inhibition in vivo led to decreased tumor cell proliferation in a dose dependent fashion associated with a decrease in tumor volume
James et al., Mol Cell Biol 2009 (Meningioma...) : Merlin does not regulate mTORC1 via the established mechanism of phosphoinositide 3-kinase-Akt or mitogen activated protein kinase/extracellular signal regulated kinase mediated TSC2 inactivation and may instead regulate TSC/mTOR signaling in a novel fashion
López-Lago et al., Mol Cell Biol 2009 (Mesothelioma) : Loss of the tumor suppressor gene NF2 , encoding merlin, constitutively activates integrin dependent mTORC1 signaling